Bosch Packaging Technology is set to showcase its new freeze dryer for pharmaceutical liquids at this year’s Achema event in Frankfurt, Germany, which will take place between 11 and 15 June.
Image: Bosch’s new freeze dryer. Photo: courtesy of Robert Bosch GmbH.
The new lyophilization system has been developed to stabilize thermolabile and delicate active ingredients such as oncological medications, vaccines or antibodies.
The new freeze dryer has been developed at the firm’s Austrian subsidiary Schoeller-Bleckmann Medizintechnik (SBM).
SBM product manager Annabel Madero said: “Short time-to-market, high quality and cost efficiency are key for pharmaceutical manufacturers.
“Our new freeze dryer is not only energy efficient, but also offers short cycle times together with reliable product quality in large batches.”
GMP-compliant freeze dryer’s modular design supports the production of small batches for clinical trials, in addition to medium and large production batches.
Water will be extracted from the drugs through sublimation during the freeze drying process, helping to protect its properties.
Bosch’s new freeze dryer enables homogenous temperature distribution in the shelves, and is designed to be used with different container sizes and formats.
For better exchange, the internal channeling and flow velocity have been optimized on the specially developed test bed.
The tilting shelves helps in quick cleaning, while the slight tilt allows water droplets to rapidly drain from the surface, enabling to reduce cleaning and drying time.
In addition, the matching interfaces assure seamless connection to the upstream filling machine with isolator technology, downstream capping machine, inspection system and secondary packaging station.
Madero further added: “Compared to powder filling, liquid filling is significantly more precise, and achieves more exact dosing.”
Bosch will also exhibit its new GKF 720 high-precision capsule filling machine for small batches at the Achema event.
The GKF 720 system, which features an advanced platform for a fully automated washable containment process, can be used to process all types of hard capsules.